Cell-to-Cell Communication and Signaling Pathways Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death
نویسندگان
چکیده
Yaming Liu,* Vikas K. Verma,* Harmeet Malhi, Greg J. Gores, Patrick S. Kamath, Arun Sanyal, Naga Chalasani, Bin Gao, and X Vijay H. Shah Division of Gastroenterology and Hepatology Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Indiana University, Indianapolis, Indiana; Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, Virginia; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland; and The First Hospital of Jilin University, Changchun, Jilin Province, China
منابع مشابه
Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death.
Interleukin-22 (IL-22) is a Th17 cell hepatoprotective cytokine that is undergoing clinical trials to treat patients with alcoholic hepatitis (AH). Lipopolysaccharide (LPS) activation of macrophage is implicated in hepatocyte cell death and pathogenesis of AH. The role of IL-22 production from macrophage, its regulation by LPS, and effects on alcohol-induced hepatocyte cell death are unexplored...
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